Individuals with Lynch syndrome have an increased risk of colorectal cancer (CRC) and other cancers. The level of CRC risk is different based on which gene they have a mutation in. Of note, MLH1 and MSH2 carriers have the highest risk of colorectal cancer, generally in the range of 43%-52% by age 70.
A recent study showed that the CRC risk to age 70 in PMS2 carriers was 9.9% for men, and 5.9% for women; and in MSH6 carriers was 10% in men, and 11.7% in women.
These findings are similar to studies that were previously reported and may help to guide cancer risk management tailored to specific Lynch syndrome genes.
Check out the article at https://www.ncbi.nlm.nih.gov/pubmed/31204389