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ICARE Newsletter Winter 2019

New Genes: GALNT12

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A gene called GALNT12 may be yet another inherited colorectal cancer gene,1 as originally suggested by prior studies.2 The current study screened almost 500 colorectal cancer patients and identified 8 rare variants that may be disease causing. The frequency of variants among colorectal cancer patients was much higher than that observed among population-matched healthy controls, providing additional evidence to suggest this gene predisposes to inherited colorectal cancer. There remains a need to collect more data to confirm these findings.

1Evans DR, et al. Hum Mutat. 2018 Aug. PMID: 29749045.
2Clarke E, et al. Hum Mutat. 2012 Jul. PMID: 22461326.

Permanent link to this article: https://inheritedcancer.net/13nlw2019/