(Version 1.2019, posted July 3, 2019)
For Individuals with Lynch Syndrome:
- The cancer risk table was updated:
- Addition of new cancer risks by specific genes: breast and bladder cancers
- Updates of cancer risks by specific genes: ovarian, prostate, gastric, pancreatic, urothelial, small bowel, and brain/CNS cancers
- Removal of reference to sebaceous neoplasms
- Recommendations for cancer risk management were updated for colon, gastric, small bowel, urothelial, and prostate cancers:
- For MSH6 carriers: consideration of colonoscopy at age 30 y or 10 y younger than age of any relative with colorectal cancer
- Initiation of gastric and small bowel cancer surveillance was updated to 40 y
- Surveillance for urothelial cancer may be considered in individuals with a family history of urothelial cancer or MSH2 mutations (especially males)
For Individuals with Attenuated Familial Adenomatous Polyposis (AFAP) and MUTYH-Associated Polyposis:
- Colonoscopy frequency was increased to every 1-2 y
For the complete updated versions of the NCCN Guidelines, please visit NCCN.org