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ICARE Newsletter Summer 2019

Updates to National Comprehensive Cancer Network (NCCN) Genetic/Familial High-Risk Assessment: Colorectal Guidelines

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(Version 1.2019, posted July 3, 2019)

For Individuals with Lynch Syndrome:

  • The cancer risk table was updated:
    • Addition of new cancer risks by specific genes: breast and bladder cancers
    • Updates of cancer risks by specific genes: ovarian, prostate, gastric, pancreatic, urothelial, small bowel, and brain/CNS cancers
    • Removal of reference to sebaceous neoplasms
  • Recommendations for cancer risk management were updated for colon, gastric, small bowel, urothelial, and prostate cancers:
    • For MSH6 carriers: consideration of colonoscopy at age 30 y or 10 y younger than age of any relative with colorectal cancer
    • Initiation of gastric and small bowel cancer surveillance was updated to 40 y
    • Surveillance for urothelial cancer may be considered in individuals with a family history of urothelial cancer or MSH2 mutations (especially males)

For Individuals with Attenuated Familial Adenomatous Polyposis (AFAP) and MUTYH-Associated Polyposis:

  • Colonoscopy frequency was increased to every 1-2 y

For the complete updated versions of the NCCN Guidelines, please visit NCCN.org

Permanent link to this article: https://inheritedcancer.net/1nls2019/