For Individuals with Lynch Syndrome:
- Surveillance for gastric and small bowel cancer now indicates there is no clear data to support this, but surveillance can be performed every 3-5 years starting at age 40
- Lack of evidence to make a recommendation for pancreatic or prostate cancer screening, beyond those already recommended through other NCCN Guideline panels
- Increased breast cancer risk was acknowledged, however there is not enough evidence to support increased screening above what is recommended for the general population
In the multi-gene testing section:
- New genes added for colorectal cancer risk included NTHL1 and MSH3 (‘biallelic’ mutations)
- Indicated lack of data to determine screening recommendations among those with single (heterozygous) mutation in MUTYH and a second degree relative with colorectal cancer
For the complete updated versions of the NCCN Guidelines, please visit NCCN.org