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ICARE Newsletter Summer 2018

Updates to NCCN Genetic/Familial High-Risk Assessment: Colorectal Guidelines

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For Individuals with Lynch Syndrome:

  • Surveillance for gastric and small bowel cancer now indicates there is no clear data to support this, but surveillance can be performed every 3-5 years starting at age 40
  • Lack of evidence to make a recommendation for pancreatic or prostate cancer screening, beyond those already recommended through other NCCN Guideline panels
  • Increased breast cancer risk was acknowledged, however there is not enough evidence to support increased screening above what is recommended for the general population

In the multi-gene testing section:

  • New genes added for colorectal cancer risk included NTHL1 and MSH3 (‘biallelic’ mutations)
  • Indicated lack of data to determine screening recommendations among those with single (heterozygous) mutation in MUTYH and a second degree relative with colorectal cancer

For the complete updated versions of the NCCN Guidelines, please visit NCCN.org

Permanent link to this article: https://inheritedcancer.net/2nls2018/