A recently published study to evaluate the risk of second cancers among PTEN mutation carriers showed that women with breast cancer had a 10-year second breast cancer cumulative risk of almost 30%. Overall, the risk of second primary cancers was almost 8-fold that of the general population, primarily due to the higher risks of cancer of the breast (almost 9-fold), thyroid (almost 6-fold), and uterus (14-fold). These findings reiterate the importance of cancer risk management options among PTEN mutation carriers in order to detect cancers early or prevent them altogether.
Ngeow J, et al. J Clin Oncol. 2014 Jun 10;32(17):1818-24. PMID: 24778394.