Through a study of over 13,000 patients with serous ovarian cancers and almost 41,000 controls, 34 genes that raise the risk for ovarian cancer were identified. Additional laboratory studies were conducted to further characterize some of these genes, suggesting that three of these new genes may be essential (HAUS6, KANLS1, and PRC1). This study has expanded the list of genes that raise the risk for ovarian cancer, and this information may eventually be used to identify those at highest risk for the disease.
Gusev, et al. Nat Genet 2019 May. PMID: 31043753