A new case series of 47 children with Li-Fraumeni syndrome diagnosed with a solid cancer at or below age 16 found that:
- Average time to another new cancer was 13.3 years
- Average survival was 9.7 years
- Time to developing new cancer and survival were MUCH shorter in those who received radiation
This study suggests that using radiation therapy to treat children with Li-Fraumeni syndrome and a solid tumor greatly raises the chance of getting a second cancer earlier. Therefore, it seems reasonable to only consider radiation when no other potentially curative option exists. If radiation cannot be avoided, second cancer risks should be minimized.
Learn more at: https://pubmed.ncbi.nlm.nih.gov/40059635/
Reference: Woodward, et al. J Natl Cancer Inst. 2025. Online ahead of print. PMID: 40059635.