A new study found that compared to those with BRCA2 variants outside exon 11, those with exon 11 mutations had:
- Lower breast cancer risk
- Higher risk for ER-negative disease
- Later age at diagnosis
Why is this important?
- Taking mutation type and location into account in cancer risk models may improve predicting individualized risk of breast cancer
- This information could be used to guide care
Learn more at: https://pubmed.ncbi.nlm.nih.gov/40288678/
Reference: Akamandisa, et al. Ann Oncol. 2025:S0923-7534(25)00170-X. Online ahead of print. PMID: 40288678.
