A new study among Black women diagnosed with breast cancer at or below age 50 found that 15.3% had germline pathogenic/likely pathogenic variants in breast and/or ovarian cancer predisposition genes.
🧬The most common were BRCA1 (7.7%), BRCA2 (4.5%), PALB2 (0.9%), and ATM (0.7%)
🧬When compared with sporadic cancers, BRCA1 carriers were far more likely to have aggressive triple-negative breast cancer (23.6% vs. 75.5%)
🧬Over half (52.8%) of BRCA1-related cases occurred by age 40
These findings highlight the critical need for genetic testing across all populations to ensure early detection for all.
Learn more at: https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.70402
Reference: Beasley et al. Cancer. 2026;132(12):e70402. PMID: 42252839.
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