A new published study of 524 families with PALB2 mutations, including our very own ICARE participants, from around the world showed increased risks of female breast, ovarian, pancreatic, and male breast cancer.
The level of risk for female breast cancer is enough to recommend cancer risk management. Cancer risk management includes screening or risk-reducing surgery. For the other cancer risks, especially in the absence of family history of these cancers, no changes in cancer risks management is advised.
Check it out at https://ascopubs.org/doi/10.1200/JCO.19.01907, and https://www.nccn.org/about/news/newsinfo.aspx?NewsID=1790.