New colon cancer and polyposis genes recently identified include NTHL1, POLE, POLD1, MSH3, and RNF43. Previous studies suggest these genes raise the risk for colon cancer and polyposis; however, recent data suggest that environmental factors may also play an important role in risk. Ultimately, these genes account for a very small fraction of polyposis cases.
For more information check out https://www.ncbi.nlm.nih.gov/pubmed/31243857 and https://www.ncbi.nlm.nih.gov/pubmed/31227763