A study comparing women with two CHEK2 mutations to one CHEK2 mutation showed that those with two mutations were:
-more likely to get breast cancer (80.6% versus 41.2%)
-more likely to be diagnosed at or below age 50 (61.3% versus 23.9%)
-more likely to have a second breast cancer diagnosis (22.6% versus 8.1%)
These findings suggest that women with two CHEK2 mutations have higher risks of cancer, which may occur at an earlier age, and may be taken into consideration when managing these women.
Check out the original article at: https://www.ncbi.nlm.nih.gov/pubmed/31993860.