A new study of almost 18,000 men with prostate cancer showed that inherited mutations in the BRCA2, ATM, and NBN genes were strongly associated with aggressive prostate cancer. Less strong associations were seen for inherited mutations in the MSH2, XRCC2, and MRE11A genes. The findings of this study suggest that knowing about inherited genes that raise the risk for prostate cancer can help guide treatment, because even men with non-aggressive prostate cancer who have these inherited mutations are at higher risk to develop advanced disease.
Darst, et al. JAMA Oncol. 2023. Online ahead of print. PMID: 3773336.