ICARE Newsletter Fall 2023

Are BRCA2 Carriers at Higher Risk for Melanoma?

At present, we are not sure because results from different studies have been inconsistent (1). For instance, one study among 173 families with a BRCA2 mutation found a 2.6-fold risk of developing melanoma (2); however, another study of 139 Dutch families with a BRCA2 mutation revealed a lower than general population risk for melanoma (3). These
inconsistent findings emphasize the need for additional research on melanoma risk among BRCA2 carriers.

1 Gumaste, et al. Br J Dermatol. 2015;172(6):1498-1506. PMID: 25524463.

2 Breast Cancer Linkage Consortium. J Natl Cancer Inst. 1999;91(15):1310-6. PMID: 10433620.

3 van Asperen, et al. J Med Genet. 2005;42(9):711-9. PMID: 16141007

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