A Polygenic Risk Score (PRS) is calculated using genetic differences throughout someone’s DNA, in combination with clinical and family history of cancer. This unique type of score may be utilized to calculate the lifetime risk of breast cancer.
Important facts about PRS’s:
- Different from BRCA1/2 testing, which look for changes in these specific genes
- Should NOT be used to diagnose a hereditary cancer predisposition.
- Should only be used in Caucasian/White women because they have not yet been studied for use in other populations.
For more information go to: https://www.ncbi.nlm.nih.gov/pubmed/30554720