A new risk prediction model was developed to assess the risk of contralateral breast cancer in BRCA1/2 carriers.
Risks are higher with:
• Younger age at first breast cancer
• Close family member with breast and/or ovarian cancer
• Mutation located near the 3′ region of the gene
Risks are lower with:
• Endocrine therapy
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Reference: Sun et al. BRCA-CRisk: A Contralateral Breast Cancer Risk Prediction Model for BRCA Carriers. J Clin Oncol. 2022. PMID: 36480783.