A new study looked at breast cancer risks in PALB2 carriers based on family history and found that risks for breast cancer were much higher in those with a family history, while additional non-genetic risk factors seemed to minimally modify risks.
To learn more read the article at: https://jamanetwork.com/journals/jamaoncology/article-abstract/2839917
Reference: O’Brien, et al. JAMA Oncol. 2025. Online ahead of print. PMID: 41066089.