The most common inherited form of urothelial cancers is Lynch Syndrome. However, a study showed that of 586 individuals with urothelial cancer, 80 had a mutation in an inherited cancer gene (14%). Mutations in several genes were observed; however, πππ2 and π½ππΎπΌ2 were both significantly associated with urothelial cancer (odds ratio of 3.7).Confirmatory studies are needed to look at this question further. In the meantime, it may be particularly important to consider genetic testing for individuals with urothelial cancer, especially those diagnosed at a young age.
Check out the original article at: https://www.ncbi.nlm.nih.gov/pubmed/31794323