BRCA1/2 have distinct characteristics and patterns of spread.
A recent study evaluated the characteristics of BRCA1/2 carriers and found that 73% ofBRCA1-associated breast cancers were triple negative; and 72% of BRCA2-associated breast cancers were hormone receptor positive. There were also distinct pattern of spread of breast cancer, with BRCA1 carriers more likely to experience lung and distant lymph node metastasis, while BRCA2 carriers were more likely to experience central nervous system and bone metastasis.
This information may help to guide care among women with BRCA1/2 mutations with breast cancer.
To read the full article visit https://www.ncbi.nlm.nih.gov/pubmed/31581314