ICARE Social Media Post February 2020

Ovarian Cancer Risks in BRCA1/2

The risk of ovarian cancer is raised in women with BRCA1/2 mutations. Recent findings suggest that higher body mass index (BMI) may further raise the risk of ovarian cancer in premenopausal BRCA1/2 carriers.

Note that all women with BRCA1/2 mutations are at high risk for ovarian cancer, and should follow current National Comprehensive Cancer Network (NCCN) management guidelines which recommend risk-reducing salpingo-oophorectomy (removal of ovaries and fallopian tubes) between age 35 and 40 for BRCA1 carriers and between age 40 and 45 for BRCA2 carriers, regardless of BMI.

Check out the article at https://www.ncbi.nlm.nih.gov/pubmed/31213659 and NCCN guidelines by creating a FREE account at https://www.nccn.org/professionals/physician_gls/pdf/genetics_bop.pdf.