ICARE Social Media Post February 2020

PMS2 and MSH6 Colorectal Cancer Risks

Individuals with Lynch syndrome have an increased risk of colorectal cancer (CRC) and other cancers. The level of CRC risk is different based on which gene they have a mutation in. Of note, MLH1 and MSH2 carriers have the highest risk of colorectal cancer, generally in the range of 43%-52% by age 70.

A recent study showed that the CRC risk to age 70 in PMS2 carriers was 9.9% for men, and 5.9% for women; and in MSH6 carriers was 10% in men, and 11.7% in women.

These findings are similar to studies that were previously reported and may help to guide cancer risk management tailored to specific Lynch syndrome genes.

Check out the article at https://www.ncbi.nlm.nih.gov/pubmed/31204389