ICARE Social Media Post March 2020

Polygenic Risk Score and Colon Cancer Risk

A Polygenic Risk Score (PRS) is calculated using genetic differences throughout someone’s DNA, in combination with clinical and family history of cancer. This score, alongside environmental and lifestyle risk factors, may help to identify people who might benefit from screening at an earlier age.

Important facts about PRS:

– It does NOT look for changes in specific cancer predisposition genes, but rather looks at changes across many genes.

– It should NOT be used to diagnose a hereditary cancer predisposition.

For more information go to https://www.ncbi.nlm.nih.gov/pubmed/31866242

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