ICARE Social Media Post March 2021

STK11: Cancer Risks and Risk Management

Gene: STK11

Cancer Risks and Management per National Comprehensive Cancer Network (NCCN) Genetic/Familial High-Risk Assessment: Colorectal Version 1.2020

Women:
Breast cancer risk: Elevated at 40-60% – Recommend annual mammogram and breast MRI starting at around age 30.

Ovarian tumor risk (typically benign sex cord/Sertoli cell tumors): Elevated at 18-21% – Recommend annual pelvic exam starting at age 18-20.

Cervical cancer risk (typically cervical adenoma malignum): Elevated at 10% – Recommend annual pelvic exam and Pap smear starting at age 18-20.

Uterus cancer risk: Elevated at 9% – Recommend annual pelvic exam starting at age 18-20.

Men & Women:
Colorectal cancer risk: Elevated at 39% – Recommend colonoscopy every 2-3 years starting in late teens.

Small intestine cancer risk: Elevated at 13% – Recommend small bowel visualization through CT or MRI enterography or video capsule endoscopy every 2-3 years starting at age 8-10.

Stomach cancer risk: Elevated 29% – Recommend upper endoscopy every 2-3 years starting in late teens.

Pancreatic cancer risk: Elevated 11-36% – Recommend MRI/MRCP or endoscopic ultrasound every 1-2 years starting at age 30-35.

Lung cancer risk: Elevated at 7%-17% – If smoker, recommend smoking cessation.

Men:
Testicular cancer risk (typically sex cord/Sertoli cell tumors): Elevated at 9% – Recommend annual testicular exam starting at age 10.

Inheritance: Autosomal dominant; thus, parents, full siblings, and children have a 50% risk for the mutation.

Family Testing: At-risk family members should consider genetic counseling and testing, including minors.

Reproductive Considerations: Option for preimplantation genetic diagnosis (PGD) may be available to ensure future generations do not inherit the known mutation. PGD is a procedure available for certain mutations to screen the embryo prior to pregnancy.

Check out the full management guidelines by creating a FREE account at https://www.nccn.org/professionals/physician_gls/pdf/genetics_colon.pdf

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