𝘐𝘯 𝘳𝘦𝘤𝘰𝘨𝘯𝘪𝘵𝘪𝘰𝘯 𝘰𝘧 𝘴𝘬𝘪𝘯 𝘤𝘢𝘯𝘤𝘦𝘳 𝘢𝘸𝘢𝘳𝘦𝘯𝘦𝘴𝘴 𝘮𝘰𝘯𝘵𝘩, we present cancer risks and management for 𝗖𝗗𝗞𝗡𝟮𝗔 per National Comprehensive Cancer Network (NCCN) Genetic/Familial High-Risk Assessment: Version 2.2021
𝗠𝗲𝗻 & 𝗪𝗼𝗺𝗲𝗻:
Melanoma risk: Elevated at 28-67% – Recommend annual full-body skin exam, regular self-examinations, and routine sun protective behaviors.
Pancreatic cancer risk: >15% – Consider MRI/MRCP and/or endoscopic ultrasound every 1 year starting at age 40 (or 10 years younger than earliest pancreatic cancer in the family).
Inheritance: Autosomal dominant; thus, parents, full siblings, and children have a 50% risk for the gene mutation.
Family Testing: At-risk family members should consider genetic counseling and testing.
Reproductive Considerations: Option for preimplantation genetic diagnosis (PGD) may be available to ensure future generations do not inherit the known gene mutation. PGD is a procedure available for certain mutations to screen the embryo prior to pregnancy.
Check out the full management guidelines by creating a 𝗙𝗥𝗘𝗘 account at: https://www.nccn.org/professionals/physician_gls/pdf/genetics_bop.pdf