A recent study found that inherited CDH1 mutations:
- were associated with lobular breast cancer, diffuse gastric cancer, and gastric cancer
- occurred in families with lobular breast cancer without gastric cancer
These findings support expansion of lobular breast cancer-centered criteria.
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Reference: Garcia-Pelaez, et al. Lancet Oncol. 2023 Jan;24(1):91-106. PMID: 36436516.