In January 2024, the American Society of Clinical Oncology (ASCO) in conjunction with the Society of Surgical Oncology released new guidelines for germline testing in patients with breast cancer, which include the following: For a full list of recommendations in this guideline, the article is available at: https://ascopubs.org/doi/10.1200/JCO.23.02225 Bedrosian, et al. J Clin Oncol. 2024;42(5):584-604. PMID:38175972. Social …
Tag: CDH1
Permanent link to this article: https://inheritedcancer.net/icare-newsletter-spring-2024-new-guidelines-released-through-asco-society-of-oncology-germline-testing-in-patients-with-breast-center/
ICARE Social Media Post January 2023
New ASCO Germline Testing in Patients With Breast Cancer Guidelines
ICARE Social Media Post January 2023
New ASCO Germline Testing in Patients With Breast Cancer Guidelines
The American Society of Clinical Oncology (ASCO) just released new guidelines for germline testing in patients with breast cancer, which include the following:๐งฌ BRCA1/2 testing should be offered to ALL patients diagnosed with breast cancer at or below age 65๐งฌ Testing for other hereditary cancer genes should also be offered based on personal and family …
Permanent link to this article: https://inheritedcancer.net/post10524/
ICARE Social Media Post October 2023
What Are Established Cancer Genes?
ICARE Social Media Post October 2023
What Are Established Cancer Genes?
There are many different inherited breast cancer genes, and different genes lead to different levels of breast cancer risk:
Permanent link to this article: https://inheritedcancer.net/post100423/
ICARE Social Media Post August 2023
Cancer Risks: Inherited CDH1 Mutations ย
ICARE Social Media Post August 2023
Cancer Risks: Inherited CDH1 Mutations ย
A recent study found that inherited CDH1 mutations: These findings support expansion of lobular breast cancer-centered criteria. Use this link to learn more: http://bit.ly/3DJa7Cs Reference: Garcia-Pelaez, et al. Lancet Oncol. 2023 Jan;24(1):91-106. PMID: 36436516.
Permanent link to this article: https://inheritedcancer.net/post82223/
ICARE Newsletter Spring 2022ย
ย CDH1 and Stomach Cancerย
ICARE Newsletter Spring 2022ย
ย CDH1 and Stomach Cancerย
A recent study of women with hereditary lobular breast cancer due to CDH1 mutations found high rates ofundetected stomach cancer (with signet ring features). The findings suggested that among CDH1 carriers, there werevery high risks for stomach cancer, even when family history of stomach cancer was absent.Gamble et al. JAMA Surg. 2021 Oct. PMID: 34643667. …
Permanent link to this article: https://inheritedcancer.net/icare-newsletter-spring-2022-cdh1-and-stomach-cancer/
Permanent link to this article: https://inheritedcancer.net/icare-newsletter-fall-2022-which-genes-are-confirmed-as-inherited-breast-cancer-genes/
Newsletter Fall 2021
Updates to NCCN Genetic/Familial High-Risk Assessment
Newsletter Fall 2021
Updates to NCCN Genetic/Familial High-Risk Assessment
Breast, Ovarian, and Pancreatic Guidelines V.1.2022: Released August 11th, 2021 Colorectal Cancer Guidelines V.1.2021: Released May 11th, 2021 Check out the full NCCN guidelines by creating a FREE account at www.nccn.org
Permanent link to this article: https://inheritedcancer.net/newsletter-fall-2021-updates-to-nccn-genetic-familial-high-risk-assessment/
ICARE Social Media Post January 2022
Gastric Cancer Risks: CDH1
ICARE Social Media Post January 2022
Gastric Cancer Risks: CDH1
Read the ๐๐๐๐ ๐๐ถ๐ณ๐จ๐ฆ๐ณ๐บ article to learn morehttps://jamanetwork.com/journals/jamasurgery/article-abstract/2785097Reference: Gamble et al. JAMA Surg. 2021 Oct 13;e215118. PMID: 34643667.
Permanent link to this article: https://inheritedcancer.net/post11122/
ICARE Social Media Post August 2021
Metastatic Breast Cancer Genes
ICARE Social Media Post August 2021
Metastatic Breast Cancer Genes
For additional information, read the Journal of Clinical Oncology article at the link below ๐ https://ascopubs.org/doi/10.1200/JCO.20.01200
Permanent link to this article: https://inheritedcancer.net/post82021/
ICARE Social Media Post August 2021
Breast Cancer Risk Among Breast Cancer Gene Carriers Varies by Polygenic Risk Score
ICARE Social Media Post August 2021
Breast Cancer Risk Among Breast Cancer Gene Carriers Varies by Polygenic Risk Score
For more information, read the ๐๐ฐ๐ถ๐ณ๐ฏ๐ข๐ญ ๐ฐ๐ง ๐๐ญ๐ช๐ฏ๐ช๐ค๐ข๐ญ ๐๐ฏ๐ค๐ฐ๐ญ๐ฐ๐จ๐บ article at the link below:https://ascopubs.org/doi/figure/10.1200/JCO.20.01992
Permanent link to this article: https://inheritedcancer.net/post81321/
ICARE Social Media Post June 2021
A Population-Based Study of Genes Previously Implicated in Breast Cancer
ICARE Social Media Post June 2021
A Population-Based Study of Genes Previously Implicated in Breast Cancer
For additional information, read the article at the following link: https://www.nejm.org/doi/10.1056/NEJMoa2005936
Permanent link to this article: https://inheritedcancer.net/post62521/
ICARE Social Media Post March 2021
Three Articles: Breast Cancer Risks
ICARE Social Media Post March 2021
Three Articles: Breast Cancer Risks
For additional information about the: ใUS-based study, visit: https://www.nejm.org/doi/full/10.1056/nejmoa2005936 ใInternational study, visit: https://www.nejm.org/doi/full/10.1056/nejmoa1913948 ใAccompanying editorial: https://www.nejm.org/doi/full/10.1056/NEJMe2035083
Permanent link to this article: https://inheritedcancer.net/post30921/
ICARE Social Media Post December 2020
CDH1 Cancer Risks
ICARE Social Media Post December 2020
CDH1 Cancer Risks
When a ๐พ๐ฟ๐1 mutation is identified, several factors should be considered to figure out what the cancer risks might be and what medical management should be advised. Specifically, differences in cancer risks among those with a ๐พ๐ฟ๐1 mutation are not well understood. Identifying a ๐พ๐ฟ๐1 mutation in families with hereditary diffuse gastric cancer (HDGC) …
Permanent link to this article: https://inheritedcancer.net/post121520/
ICARE Social Media Post October 2020
CDH1: Cancer Risks and Risk Management
ICARE Social Media Post October 2020
CDH1: Cancer Risks and Risk Management
Gene: ๐พ๐ฟ๐๐ญ Cancer Risks and Management per NCCN Genetic/Familial High-Risk Assessment: Breast/Ovarian/Pancreatic Version 1.2021 and Gastric Version 3.2020: ๐ช๐ผ๐บ๐ฒ๐ป: Breast cancer risk: Elevated at 55% – Recommend annual mammogram starting at age 30; consider breast MRI with contrast starting at age 30. ๐ ๐ฒ๐ป ๐ฎ๐ป๐ฑ ๐ช๐ผ๐บ๐ฒ๐ป: Stomach cancer risk: Elevated at 83% for women, and 67% …
Permanent link to this article: https://inheritedcancer.net/post103020/
ICARE Social Media Post August 2020
Optimal Timing of Prophylactic Gastrectomy for CDH1 Carriers
ICARE Social Media Post August 2020
Optimal Timing of Prophylactic Gastrectomy for CDH1 Carriers
Individuals with a CDH1 mutation and classic personal and family history of diffuse gastric (stomach) cancer have a very high risk of developing and dying from stomach cancer, if they do not have preventive surgery to remove their stomach. A simulation study to assess prophylactic total gastrectomy (PTG; the removal of the stomach to prevent …
Permanent link to this article: https://inheritedcancer.net/post82120/
ICARE Social Media Post July 2020
BRCA1/2 and Other Gene Carriers with Breast Cancer Donโt Always Receive Recommended Treatment
ICARE Social Media Post July 2020
BRCA1/2 and Other Gene Carriers with Breast Cancer Donโt Always Receive Recommended Treatment
BRCA1/2 and other gene mutation carriers with early stage breast cancer are not always receiving cancer treatment as recommended by national guidelines. Even though more and more people have been tested for hereditary cancer over the years, using this information accurately to guide treatment has not been as successful. These findings highlight the need for …
Permanent link to this article: https://inheritedcancer.net/post71020/
ICARE Social Media Post May 2020
CDH1: Gastric and Breast Cancer Risks
ICARE Social Media Post May 2020
CDH1: Gastric and Breast Cancer Risks
CDH1 mutation carriers are at higher risk for diffuse gastric cancer (men and women) and lobular breast cancer (women). Current strategies to manage high risks of gastric cancer include prophylactic gastrectomy (i.e., removal of the stomach), which can have severe physical and psychological implications. A recent study found that men have a higher risk of …
Permanent link to this article: https://inheritedcancer.net/post50520/
Permanent link to this article: https://inheritedcancer.net/1nls2015/
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