Below are publications related to the ICARE Initiative that focus on inherited cancer predisposition, including studies focused on populations with cancer health disparities. Publications that include de-identified data from ICARE participants are reflected by an asterisk (*). These types of research efforts enable us to learn more about inherited cancer and determine how to better manage those with inherited cancer and their at-risk family members.
2024
- Garmendia et al., Genes: Comparing Cancer Risk Management between Females with Truncating CHEK2 1100delC versus Missense CHEK2 I157T Variants *
- Narod et al., J Natl Cancer Inst: Incidence of Peritoneal Cancer Following Oophorectomy among BRCA1 and BRCA2 Mutation Carriers *
- Narod et al., Hered Cancer Clin Pract: The risk of skin cancer in women who carry BRCA1 or BRCA2 mutations *
- Lubinski et al., JAMA Oncol: MRI Surveillance and Breast Cancer Mortality in Women with BRCA1 and BRCA2 Sequence Variations *
- Kotsopoulos et al., JAMA Oncol: Bilateral Oophorectomy and All-Cause Mortality in Women with BRCA1 and BRCA2 Sequence Variations *
- Metcalfe et al., Br J Cancer: Risk-reducing mastectomy and breast cancer mortality in women with a BRCA1 or BRCA2 pathogenic variant: an international analysis *
2023
- Dean et al., Genet Med: Factors that Differentiate Cancer Risk Management Decisions Among Females with Pathogenic/Likely Pathogenic Variants in PALB2, CHEK2, and ATM *
- Pal et al., Gen Test Mol Biomarkers: Inherited Cancer Knowledge Among Black Females with Breast Cancer Before and After Viewing a Web-Based Educational Video
- Cragun et al., PEC Innovation: Applying the framework for developing and evaluating complex interventions to increase family communication about hereditary cancer
2022
- Reid et al., JAMA Oncol: Receipt of Bilateral Mastectomy Among Women with Hereditary Breast Cancer *
- Reid et al., Breast Cancer Res Treat: An overview of genetic services delivery for hereditary breast cancer
2021
- Reid et al., Breast Cancer Res Treat: Impact of molecular subtype and race on HR+, HER2- breast cancer survival
- Sanderson et al., Cancer Epidemiol Biomarkers Prev: A Pooled Case-only Analysis of Reproductive Risk Factors and Breast Cancer Subtype Among Black Women in the Southeastern United States
- Chunling et al., N Engl J Med: A Population-Based Study of Genes Previously Implicated in Breast Cancer *
- Dean et al., Patient Educ Couns: Sharing Genetic Test Results with Family Members of BRCA, PALB2, CHEK2, and ATM Carriers *
- Tezak et al., J Cancer Educ: Qualitative Methods for Refining a Web-Based Educational Tool for Patients Focused on Inherited Cancer Predisposition
2020
- Reid et al., Expert Rev Mol Diagn: Strategies to enhance identification of hereditary breast cancer gene carriers
- Reid et al., Breast J: Update on multi-gene panel testing and communication of genetic test results
- Kotsopoulos et al., Gynecol Oncol: Breastfeeding and the risk of epithelial ovarian cancer among women with a BRCA1 or BRCA2 mutation
- Cragun et al., J Natl Compr Canc Netw: A Web-Based Tool to Automate Portions of Pretest Genetic Counseling for Inherited Cancer
- Conley et al., Psychooncology: Patterns and covariates of benefit finding in young Black breast cancer survivors: A longitudinal, observational study
- Conley et al., Breast J: Acceptability and outcomes of multigene panel testing among young Black breast cancer survivors
- Palmer et al., J Natl Cancer Inst: Contribution of Germline Predisposition Gene Mutations to Breast Cancer Risk in African American Women
- Reid et al., Genet Med: Disparities in BRCA counseling across providers in a diverse population of young breast cancer survivors
- Conley et al., J Genet Couns: The big reveal: Family disclosure patterns of BRCA genetic test results among young Black women with invasive breast cancer
- Cragun et al., J Genet Couns: Family communication of genetic test results among women with inherited breast cancer genes *
- Cragun et al., Breast Cancer Res Treat: Cancer Risk Management Among Female BRCA1/2, PALB2, CHEK2, and ATM Carriers *
- Weidner et al., Cancer: Breast Cancer Screening Implications of Risk Modeling Among Female Relatives of ATM and CHEK2 Carriers *
2019
- Conley et al., Ann Surg Oncol: Impact of Genetic Testing on Risk-Management Behavior of Black Breast Cancer Survivors: A Longitudinal, Observational Study
- Yang et al., J Clin Oncol: Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families *
- Pal et al., Genet Med: Points to consider: is there evidence to support BRCA1/2 and other inherited breast cancer genetic testing for all breast cancer patients? A statement of the American College of Medical Genetics and Genomics (ACMG)
- Scherr et al., Heatlh Commun: A Framework for Pilot Testing Health Risk Video Narratives
- Wang et al., Clin Cancer Res: Sex Disparity Observed for Oncotype DX Breast Recurrence Score in Predicting Mortality Among Patients with Early Stage ER-Positive Breast Cancer
- Wang et al., JAMA Oncol: Overall Mortality After Diagnosis of Breast Cancer in Men vs Women
- Metcalfe et al., Br J Cancer: International trends in the uptake of cancer risk reduction strategies in women with a BRCA1 or BRCA2 mutation *
- Cragun et al., Genet Test Mol Biomarkers: Genetic Testing Across Young Hispanic and Non-Hispanic White Breast Cancer Survivors: Facilitators, Barriers, and Awareness of the Genetic Information Nondiscrimination Act
- Kasting et al., Psychooncology: A randomized controlled intervention to promote readiness to genetic counseling for breast cancer survivors
2018
- Reblin et al., Breast J: Health beliefs associated with readiness for genetic counseling among high risk breast cancer survivors
- Gonzalez et al., Psychooncology: Psychosocial Impact of BRCA Testing in Young Black Breast Cancer Survivors
- Cragun et al., Cancer: Racial disparities in BRCA testing and cancer risk management across a population-based sample of young breast cancer survivors
- Vicuña et al., J Community Genet: Preferences for multigene panel testing for hereditary breast cancer risk among ethnically diverse BRCA-uninformative families
- Cragun et al., Seminars in Colon and Rectal Surgery: Complexities of genetic screening and testing in hereditary colorectal cancer *
- Powers et al., Surg Oncol Clin N Am: Considerations in Testing for Inherited Breast Cancer Predisposition in the Era of Personalized Medicine *
- Pal et al., Oncology Issues: The Inherited Cancer Registry (ICARE) Initiative: An Academic-Community Partnership for Patients and Providers *
- Kotsopoulos et al., Gynecol Oncol: Age-specific ovarian cancer risks among women with a BRCA1 or BRCA2 mutation *
- Kotsopoulos et al., Breast Cancer Res Treat: Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers *
- Kim et al., Int J Epidemiol: Prospective evaluation of body size and breast cancer risk among BRCA1 and BRCA2 mutation carriers *
- Metcalfe et al., Clin Genet: The risk of breast cancer in BRCA1 and BRCA2 mutation carriers without a first-degree relative with breast cancer *
- Ko et al., Int J Cancer: The association between smoking and cancer incidence in BRCA1 and BRCA2 mutation carriers *
- Kotsopoulos et al., JAMA Oncol: Hormone Replacement Therapy After Oophorectomy and Breast Cancer Risk Among BRCA1 Mutation Carriers *
2017
- Rivers et al., Ethn Health: A community-academic partnership to explore informational needs of African American women as a primer for cancer clinical trial recruitment
- Vadaparampil et al., Breast Cancer Res Treat: Health-related Quality of Life in Black Breast Cancer Survivors with and without Triple Negative Breast Cancer (TNBC)
- Akbari et al., Fam Cancer: Correlation between germline mutations in MMR genes and microsatellite instability in ovarian cancer specimens
- Pal et al., South Med J: Identification and Management of TP53 Gene Carriers Detected Through Multigene Panel Testing *
- Cragun et al., Expert Rev Mol Diagn: Care delivery considerations for widespread and equitable implementation of inherited cancer predisposition testing *
- Sajjad et al., Genes: An Exploratory Study to Determine Whether BRCA1 and BRCA2 Mutation Carriers Have Higher Risk of Cardiac Toxicity *
2016
- Bonner et al., Breast J: Recruitment of a Population-Based Sample of Young Black Women with Breast Cancer through a State Cancer Registry
- Scherr et al., Patient Educ Couns: Tracking the Dissemination of a Culturally Targeted Brochure to Promote Awareness of Hereditary Breast and Ovarian Cancer among Black Women
- Cragun et al., Healthcare: Hereditary Cancer: Example of a Public Health Approach to Ensure Population Health Benefits of Genetic Medicine *
- Gronwald et al., Fertil Steril: Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation *
- Kotsopoulos et al., J Natl Cancer Inst: Bilateral Oophorectomy and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers *
- Cragun et al., Genet Test Mol Biomarkers: Evolution of Hereditary Breast Cancer Genetic Services: Are Changes Reflected in the Knowledge and Clinical Practices of Florida Providers? *
- Iqbal et al., Br J Cancer: The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study *
2015
- Cragun et al., Applied Clinical Research, Clinical Trials and Regulatory Affairs: Evaluation of a Genetic Counseling Aid for Hereditary Breast and Ovarian Cancer
- Segev et al., Eur J Gynaecol Oncol: Survival in women with ovarian cancer with and without microsatellite instability
- Jhuraney et al., J Med Genet: BRCA1 Circos: a visualisation resource for functional analysis of missense variants
- Cragun et al., J Genet Couns: Applying public health screening criteria: how does universal newborn screening compare to universal tumor screening for Lynch syndrome in adults with colorectal cancer?
- Cragun et al., Breast Cancer Res Treat: Factors associated with genetic counseling and BRCA testing in a population-based sample of young Black women with breast cancer
- Pal et al., Cancer: A high frequency of BRCA mutations in young black women with breast cancer residing in Florida
- Metcalfe et al., Ann Surg Oncol: Long-Term Psychosocial Functioning in Women with Bilateral Prophylactic Mastectomy: Does Preservation of the Nipple-Areolar Complex Make a Difference? *
- Segev et al., Fam Cancer: Risk factors for endometrial cancer among women with a BRCA1 or BRCA2 mutation: a case control study *
- Kotsopoulos et al., Int J Cancer: Factors influencing ovulation and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers *
- Vadaparampil et al., Clin Genet: Pre-test Genetic Counseling Services for Hereditary Breast and Ovarian Cancer Delivered by Non-Genetics Professionals in the State of Florida *
- Cragun et al., Genet Med: Differences in BRCA Counseling and Testing Practices Based on Ordering Provider Type *
- Fecteau et al., Next Generation Sequencing in Cancer Research, Volume 2: Chapter entitled ‘Clinical Considerations in the Conduct of Cancer Next Generation Sequencing Testing and Genetic Counseling’ *
2014
- Lee et al., Genet Test Mol Biomarkers: Association between IHC and MSI testing to identify mismatch repair-deficient patients with ovarian cancer
- Pal et al., J Community Genet: BRCA sequencing and large rearrangement testing in young Black women with breast cancer
- Cragun et al., Clin Genet: Panel-based testing for inherited colorectal cancer: a descriptive study of clinical testing performed by a US laboratory
- Cragun et al., Genet Med: Comparing universal Lynch syndrome tumor-screening programs to evaluate associations between implementation strategies and patient follow-through
- Pal et al., Clin Genet: Modes of delivery of genetic testing services and the uptake of risk management options in BRCA1 and BRCA2 carriers *
- Radford et al., J Genet Couns: Factors which impact the delivery of genetic risk assessment services focused on inherited cancer genomics: expanding the role and reach of certified genetics professionals *
- Kotsopoulos et al., Breast Cancer Res Treat: Timing of oral contraceptive use and the risk of breast cancer in BRCA1 mutation carriers *
- Phelan et al., Br J Cancer: Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers: results from a follow-up study *
- Finch et al., J Clin Oncol: Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation *
- Gronwald et al., Breast Cancer Res Treat: Duration of tamoxifen use and the risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers *
- Giannakeas et al., Breast Cancer Res Treat: Mammography screening and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a prospective study *
- Quinn et al., Genet Test Mol Biomarkers: Contrasting the ethical perspectives of biospecimen research among individuals with familial risk for hereditary cancer and biomedical researchers: implications for researcher training
2013
- McLaughlin et al., J Natl Cancer Inst: Long-term ovarian cancer survival associated with mutation in BRCA1 or BRCA2
- Pal et al., Breast J: Early onset breast cancer in a registry-based sample of African-american women: BRCA mutation prevalence, and other personal and system-level clinical characteristics
- Pal et al., Fam Cancer: Interest of individuals from BRCA families to participate in research studies focused on male BRCA carriers
- Quinn et al., Am J Med Genet A: Risk terminology in biobanking and genetic research: what’s in a name?
- Pal et al., Genet Test Mol Biomarkers: A statewide survey of practitioners to assess knowledge and clinical practices regarding hereditary breast and ovarian cancer *
- Semple et al., Ann Surg Oncol: International rates of breast reconstruction after prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers *
- Cragun et al., J Cancer Educ: Educational needs and preferred methods of learning among Florida practitioners who order genetic testing for hereditary breast and ovarian cancer *
- Cragun et al., ISRN Oncol: Identification, Evaluation, and Treatment of Patients with Hereditary Cancer Risk within the United States *
- Segev et al., Gynecol Oncol: The incidence of endometrial cancer in women with BRCA1 and BRCA2 mutations: an international prospective cohort study *
- Finch et al., Fertil Steril: Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation *
- Senst et al., Clin Genet: Parental origin of mutation and the risk of breast cancer in a prospective study of women with a BRCA1 or BRCA2 mutation *
- Segev et al., Int J Gynecol Cancer: Risk factors for ovarian cancers with and without microsatellite instability
2012
- Cragun et al., Genet Test Mol Biomarkers: Colorectal cancer survivors’ interest in genetic testing for hereditary cancer: implications for universal tumor screening
- Quinn et al., Genet Med: High-risk consumers’ perceptions of preimplantation genetic diagnosis for hereditary cancers: a systematic review and meta-analysis
- Vadaparampil et al., Support Care Cancer: A pilot study to examine patient awareness and provider discussion of the impact of cancer treatment on fertility in a registry-based sample of African American women with breast cancer
- Kumar et al., Hereditary Genet: Metformin- A Promising Agent for Chemoprevention in BRCA1 Carriers
- Kotsopoulos et al., Cancer Epidemiol Biomarkers Prev: Oophorectomy after Menopause and the Risk of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers *
- Kotsopoulos et al., Breast Cancer Res: Breastfeeding and the Risk of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers *
- Iqbal et al., Br J Cancer: The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers *
- Pal et al., Cancer Control: Genetic risk assessments in individuals at high risk for inherited breast cancer in the breast oncology care setting
- Pal et al., Br J Cancer: Frequency of mutations in mismatch repair genes in a population-based study of women with ovarian cancer
- Coppola et al., Anticancer Res: Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer
