A new study suggests that BRIP1 might be the THIRD most common gene for inherited ovarian cancer. BRCA1/2 mutations were found in almost 15%, while the frequency of mutations in other homologous recombination repair (HRR) genes among unselected ovarian cancer patients was:
- BRIP1: 1.1%
- PALB2: 0.8%
- RAD51C: 0.4%
- RAD51D: 0.4%
Why is this important?
Testing in patients with ovarian cancer through inherited cancer multi-gene panel tests detected mutations in non-BRCA1/2 HRR genes in 2% to 3% of patients, with the largest contributor being BRIP1.
Learn more at: https://pubmed.ncbi.nlm.nih.gov/39096152/
Reference: Morgan, et al. Genet Med. 2024;26(10):101230. PMID: 39096152.