ICARE Newsletter Spring 2026

NCCN Guidelines Insights Article

JNCCN released an article in the February issue with insights on:

Prostate cancer screening:

  • Review of genes/risks: BRCA1/2, HOXB13, ATM, CHEK2, MSH2, PALB2, and TP53
  • Prostate MRI recommended screening is done in experienced high-volume centers after an in-depth discussion

Pancreatic cancer screening:

  • Screening without need for family history: CDKN2A, STK11, ATM, BRCA2
  • Family history needed: BRCA1, MSH2, MLH1, MSH6, EPCAM, PALB2, TP53

Testing for non-epithelial ovarian cancer:

  • SCCOHT: test for DICER1
  • SCTAT: test for STK11 (Peutz-Jeghers)
  • Given rarity, consultation with expert may be considered

Cheng, et al. J Natl Compr Cancer Netw. 2026:24(2):2-10. PMID: 41671423.Article available at: https://jnccn.org/view/journals/jnccn/24/2/article-p2.xml. Social media post available at: https://www.facebook.com/share/p/1Rk6tvn2AB/

Permanent link to this article: https://inheritedcancer.net/nls20261/