A new study of >2,000 BRCA1/2 carriers found 71 cases of ovarian/fallopian tube carcinoma following a breast cancer diagnosis. Of these 71 cases, 66 were among BRCA1 carriers and 5 were among BRCA2 carriers. BRCA1 carriers had a 5-fold higher risk of ovarian cancer compared to BRCA2 carriers. The risk of ovarian/fallopian tube cancer at 15 years in women WITH versus WITHOUT a prior history of breast cancer was 10.8% and 25.9%, respectively. These findings show that preventive removal of the ovaries and fallopian tubes (i.e., preventive surgery) remains strongly recommended for BRCA1/2 mutation carriers regardless of whether they have a history of breast cancer.
Apostol, et al. Gynecol Oncol. 2025;201:44-52. PMID: 40784323. Article available at: https://pubmed.ncbi.nlm.nih.gov/40784323/. Social media post available at: https://www.facebook.com/share/p/1DyBkt1wn1/