The new NCCN Genetic/Familial High-Risk Assessment Guidelines Version 1.2026 (released June 16th, 2026) are now called: Colorectal, Endometrial, Esophageal, and Gastric Cancer Guidelines
NOTE: Esophageal cancer newly added to name of this guideline!
In these guidelines, an entire section was added on hereditary esophageal cancer (see pages HESOPH-1 and HESOPH-2:
PRINCIPLES OF GENETIC RISK ASSESSMENT FOR ESOPHAGEAL CANCERS)
Criteria include those for:
- Squamous cell carcinoma
- Adenocarcinoma
Syndromes associated with increased risk of Esophageal Squamous Cell Carcinoma, for which screening endoscopy recommended:
Tylosis with esophageal cancer
- May be due to RHBDF2 gene
- Average age at presentation of 45 years
- Lifetime risk to age 80 of >95%
Fanconi anemia
- Risk is 500-700 fold that of the general population
To access these new guidelines, create a free account at NCCN.org and visit the following link: https://www.nccn.org/professionals/physician_gls/pdf/genetics_ceeg.pdf
Through ICARE, we aspire to share cancer-related information that may be of interest. If you have questions or clarifications, please direct them to your healthcare provider.
