Updates to National Comprehensive Cancer Network (NCCN) Genetic/Familial High-Risk Assessment: Colorectal Guidelines (Version 1.2020, posted July 21, 2020)
For individuals with Lynch Syndrome:
- Cancer risks were updated based on information from recent studies:
- Main updates included cancer risks in PMS2 (endometrial, ovarian, and prostate cancer), MSH2 and EPCAM (prostate and brain cancer), and MSH6 (prostate cancer)
- Cancer risk management was updated to include:
- Recommendations that differ across the various Lynch Syndrome genes, based on their level and type of cancer risk
- Specific dosing of aspirin use for MLH1, MSH2, EPCAM, and MSH6 (i.e.,600 mg/daily)
- Age of colonoscopy for MSH6 and PMS2 was changed to start a bit later, at age 30
For individuals with Familial Adenomatous Polyposis (FAP):
- Thyroid cancer screening through ultrasound was spaced out to every 2-5 years (from every year)
NCCN bulletin available at:
https://www.nccn.org/about/news/ebulletin/ebulletindetail.aspx?ebulletinid=294
Updated NCCN guidelines are available free-of-charge at:
https://www.nccn.org/professionals/physician_gls/pdf/genetics_colon.pdf