Using information from twelve prior population-based studies, a modeling analysis was done to look at when to start mammography and breast MRI in females with inherited mutations in genes including ATM and CHEK2. Overall, findings showed that starting annual MRI screening between age 30 to 35 and mammography at age 40 may lower death from breast cancer by more than half in female CHEK2 and ATM carriers. Since this report was published earlier this year, the NCCN guidelines were changed to recommend starting breast MRI screening in female CHEK2 and ATM carriers between age 30 to 35. These findings highlight how new research is used to update national practice guidelines.
Lowry et al. JAMA Oncol. 2022;8(4):587-596. PMID: 35175286. Social media post April 1 st, 2022. Available at: https://tinyurl.com/post4012022