What elements are most important in the collection of family history?
- Cancer details in first- and second-degree relatives and the patient’s ethnicity.
When and how to use multigene panel testing when indicated?
- When more than one gene is relevant based on personal and/or family history, multigene panel testing should be offered.
Which genes should be tested based on cancer type?
- Table 1 outlines genes based on cancer type, including those more versus less strongly recommended.
Among patients with tumor testing, who should be offered germline testing?
- Any patient who meets criteria for germline genetic testing should be offered germline testing regardless of results from tumor testing.
- Even those not meeting criteria based on personal or family history who have a mutation identified through tumor testing in a gene listed in Table 2 under the outlined circumstances should be offered germline testing.
For a full list of recommendations in this guideline, the article is available at: https://ascopubs.org/doi/10.1200/JCO.24.00662
Tung, et al. J Clin Oncol. 2024;42(21):2599-2615. PMID: 38759122. Social media post May 21st, 2024. Available at: https://tinyurl.com/post52124