In a new study of unselected women with ovarian cancer, BRIP1 was the third most common gene for inherited ovarian cancer at a frequency of 1.1%, following BRCA1/2 which were found in 14.8%. Other inherited ovarian cancer genes included PALB2 (0.8%), RAD51C (0.4%), and RAD51D (0.4%). Beyond BRCA1/2 testing, additional testing through inherited cancer multi-gene panel tests detected mutations in an additional 2% to 3% of patients.
Morgan, et al. Genet Med. 2024;26(10):101230. PMID: 39096152. Article available at: https://pubmed.ncbi.nlm.nih.gov/39096152/. Social media post available at: https://www.facebook.com/share/p/1B6soiHPUF/