PREMM5 is a model to estimate the risk for having Lynch Syndrome.
PREMMplus is a model that estimates risks in 19-cancer risk genes, including Lynch Syndrome genes, BRCA, and other genes.
A new study that compared PREMM5 and PREMMplus found that PREMMplus was just as good as PREMM5 in identifying patients with Lynch Syndrome. PREMMplus also goes beyond this condition to identify individuals at risk for other inherited cancer risk genes.
Given that multigene panels are frequently used for inherited cancer gene testing, a broader approach to assessing risks is sometimes desired.
Learn more at: https://pubmed.ncbi.nlm.nih.gov/39772830/
Reference: Biller, et al. JCO Precis Oncol. 2025. PMID: 39772830.