A new study among BRCA1/2 carriers without a prior breast cancer diagnosis, which included ICARE participants, showed that HRT use did NOT lead to a significant increase in breast cancer risk and estrogen alone HRT may be protective.
Why is this important?
Women with BRCA1/2 mutations have high risk of ovarian cancer; thus, removing the ovaries at an early age is strongly recommended. HRT is an effective way to mitigate the health issues that go along with early menopause and this study shows that HRT can be used safely in this population.
Learn more at: https://pubmed.ncbi.nlm.nih.gov/41403285/
Reference: Kotsopoulos, et al. J Natl Cancer Inst. 2025:djaf363. PMID: 41403285.