Individuals with a CDH1 mutation and classic personal and family history of diffuse gastric (stomach) cancer have a very high risk of developing and dying from stomach cancer, if they do not have preventive surgery to remove their stomach.
A simulation study to assess prophylactic total gastrectomy (PTG; the removal of the stomach to prevent stomach cancer) found the ideal age for this surgery was 39 years for men and 30 years for women, when quality-adjusted life-years (QALYs) are the primary endpoint. This analysis took into account risk of death from cancer, as well as life expectancy.
These ages for PTG are older than those of current recommendations. Additional studies are needed to confirm these findings and determine ideal age of surgeries among these individuals.
Check out the original article at: https://www.ncbi.nlm.nih.gov/pubmed/31220641