More than 40% of patients with pheochromocytoma or paraganglioma, regardless of age and family history, carry an inherited gene mutation. Given that gene mutation carriers may benefit from gene-specific cancer screening, all individuals diagnosed with one of these tumors should seek genetic counseling to discuss genetic testing options.
Genes that predispose to pheochromocytoma and paraganglioma include: SDHA, SDHAF2, SDHB, SDHC, SDHD, TMEM127, MAX, RET, VHL, and NF1.
Check out the article at https://www.nejm.org/doi/full/10.1056/NEJMra1806651?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed