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ICARE Newsletter Summer 2019

New Information About Cancer Risks for Inherited Cancer Genes: CHEK2

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In a study of inherited mutations in the CHEK2 gene, findings suggest there were two specific mutations that could predispose men to testicular germ cell tumors (TGCT). Specifically, 205 men with these tumors were tested for 48 DNA repair genes, and findings were then tested in other patient populations. These findings suggest that CHEK2 mutations might predispose to TGCT, and also identify new avenues to explore treatments.

AlDubayan, et al. JAMA Oncol. 2019 Apr. PMID: 30676620.

Permanent link to this article: https://inheritedcancer.net/7nls2019/