A new international study in over 8000 BRCA1/2 carriers, which included data from ICARE participants, showed risk of pancreatic cancer to age 80 in BRCA1 was 2.2% (95% CI: 1.1%-4.3%) and in BRCA2 was 2.7% (95% CI: 1.3%-5.2%). Of the 34 BRCA1/2 carriers with pancreatic cancer, only 2 had a close (first-degree) relative with pancreatic cancer, suggesting that family history didn’t predict who would get these cancers. Of those with pancreatic cancer, less than 10% were alive after 5 years, showing the urgency to find strategies for prevention and early detection.
Katona, et al. Cancer. 2025;131(1):e35666. PMID: 39611336. Article available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11694537/. Social media post available at: https://tinyurl.com/post12122024.