The European Society of Medical Oncology (ESMO) evaluated breast cancer susceptibility genes on the basis of cancer-related mortality to help guide which genes should be included in genetic testing for inherited breast cancer.
Those that may lead to patients living longer: BRCA1, BRCA2, PALB2, RAD51C, RAD51D, TP53 (for breast cancer diagnosed < age 40), and BRIP1 (possibly)
Other genes that might help estimate risks although uncertain they lead to patients living longer: CHEK2 and ATM
The group recommended strongly against inclusion of ‘syndromic’ genes such as STK11, PTEN, NF1, and CDH1
Learn more at: https://pubmed.ncbi.nlm.nih.gov/40523834/
Reference: Turnbull et al. Ann Oncol. 2025;36(8):853-865. PMID: 40523834.
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