ICARE Social Media Post March 2024

 Risk Management Strategies for Women with BRCA1/2


Two new research studies that 𝗶𝗻𝗰𝗹𝘂𝗱𝗲𝗱 𝗜𝗖𝗔𝗥𝗘 𝗽𝗮𝗿𝘁𝗶𝗰𝗶𝗽𝗮𝗻𝘁𝘀 showed that risk of death is lowered among BRCA1/2 carriers with 1) MRI screening for breast cancer and 2) removal of both ovaries and fallopian tubes. 💡 In the first study, MRI screening greatly lowered the risk of death from breast cancer (hazard ratio of 0.23) with a ‘statistically significant’ reduction seen among BRCA1 carriers, but not BRCA2 carriers. In the second study, removal of the ovaries and fallopian tubes greatly lowered the risk of death for any cause (‘all-cause mortality’) with age-adjusted hazard ratios of 0.28 for BRCA1 carriers and 0.43 for BRCA2 carriers. Learn more at the links below!

Reference: Lubinski, et al. JAMA Oncol. 2024. PMID: 38421676.

Reference: Kotsopoulos, et al. JAMA Oncol. 2024. PMID: 38421677.

Permanent link to this article: https://inheritedcancer.net/post3524/