A new study among patients with Familial Adenomatous Polyposis (FAP), most of whom had a their colon removed to prevent cancer, found that although risk-reducing colectomy is now standard practice in FAP patients, colorectal cancer remains the most common cancer and cause of death in these patients. Recognizing cases of FAP that are ‘de novo’ (meaning first person in the family to have the mutation) will remain a challenge, but more careful attention to screening of the upper gastrointestinal tract (i.e., endoscopy) in those with established FAP should be a priority.
To learn more, read the full article at: https://pubmed.ncbi.nlm.nih.gov/39932215/
Reference: Feldman, et al. Dis Colon Rectum. 2025;68(5):531-543. PMID: 39932215.