Breast and Ovarian Management Based on Genetic Test Resultsa
Recommend Breast MRIc
|Recommend Risk-reducing salpingo-oophorectomy||Discuss Option of Risk-reducing mastectomy|
|Intervention warranted based on gene and/or risk level||ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, PTEN, STK11, TP53||BRCA1, BRCA2, Lynch syndromee||BRCA1, BRCA2, CDH1, PTEN, TP53|
|Insufficient evidence for
|BARD1, BRIP1||BARD1, BRIP1, PALB2, RAD51C, RAD51D||ATM, BARD1, CHEK2, PALB2, STK11|
Note: To access full guidelines document, refer to www.nccn.org
aOther genes may be included in mutli-gene testing. cSee NCCN Guidelines for Breast Cancer Screening and Diagnosis. dMay be modified based on family history or specific gene mutation. eSee NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal.