Released September 8th, 2020:
Genetic testing criteria by cancer type:
Breast Cancer:
- Broadened to include relatives with ALL grades of prostate cancer (not just high-grade)
- Having multiple breast cancer diagnoses no longer depends on whether the diagnoses were on two different breasts
Prostate Cancer:
- Now includes cribriform histology and ANY risk group (not just high-grade prostate cancer)
- Only first-degree relatives should be offered genetic testing
Pancreatic Cancer:
- Only first-degree relatives should be offered genetic testing
Released September 8th, 2020:
Breast cancer risk management recommendations by gene:
- NBN: high-risk breast screening was removed as there is insufficient evidence to support high breast cancer risks
- BARD1: added consideration for high-risk breast screening starting at age 40
- RAD51C & RAD51D: risks for triple-negative breast cancer were broadened to include potential increase in female breast cancer risk
- BRCA1/2: in men with gynecomastia, added consideration for annual mammogram at age 50 (or 10 years before earliest male breast cancer diagnosis in the family)
Released November 20th, 2020:
Inherited cancer gene tables expanded to include more detailed risk information, level of risk, and strength of evidence
Check out the full NCCN guidelines by creating a FREE account at: https://www.nccn.org/professionals/physician_gls/pdf/genetics_bop.pdf