Breast and Ovarian Management Based on Genetic Test Resultsa
|
Recommend Breast MRIc |
Recommend Risk-reducing salpingo-oophorectomy | Discuss Option of Risk-reducing mastectomy | |
| Intervention warranted based on gene and/or risk level | ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, PTEN, STK11, TP53 | BRCA1, BRCA2, Lynch syndromee | BRCA1, BRCA2, CDH1, PTEN, TP53 |
| Insufficient evidence for interventionb |
BARD1, BRIP1 | BARD1, BRIP1, PALB2, RAD51C, RAD51D | ATM, BARD1, CHEK2, PALB2, STK11 |
Note: To access full guidelines document, refer to www.nccn.org
aOther genes may be included in mutli-gene testing. cSee NCCN Guidelines for Breast Cancer Screening and Diagnosis. dMay be modified based on family history or specific gene mutation. eSee NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal.