ICARE Newsletter Spring 2024

National Comprehensive Cancer Network (NCCN) Guideline Updates

Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic Cancer Released February 12th, 2024 (V3.2024)

Check out the full guidelines by creating a FREE account at www.nccn.org/professionals/physician_gls/pdf/genetics_bop.pdf

Contralateral breast cancer risks in these updated guidelines:

Expanded guidance about gynecologic cancers in BRCA1/2 carriers:

  • Reproductive considerations
  • Non-surgical and surgical risk reduction
  • Salpingectomy
  • Hysterectomy considerations
  • Hormone replacement therapy (HRT) after risk-reducing removal of the ovaries

Some highlights related to HRT include:

  • Premature menopause due to risk-reducing removal of the ovaries and fallopian tubes can cause detriments to quality-of-life, as well as bone, cardiovascular, psychosocial, neurologic, and sexual health.
  • HRT can reduce these risks and is generally not contraindicated.
  • Thus, HRT should be discussed with premenopausal patients who do not have a personal history of breast cancer.

Genetic/Familial High-Risk Assessment: Colorectal Cancer Released October 30th, 2023 (V2.2023)

Check out the full guidelines by creating a FREE account at www.nccn.org/professionals/physician_gls/pdf/genetics_colon.pdf

  • Test Selection modified: Germline panel testing should include at a minimum the following colorectal cancer risk-associated genes: APC, MUTYH, MLH1, MSH2, MSH6, PMS2, EPCAM, BMPR1A, SMAD4, PTEN, STK11, TP53
  • MUTYH monoallelic pathogenic variant/heterozygotes (carrier): revised to indicate “No increased risk.”
  • Criteria for the Evaluation of Lynch Syndrome Based on Personal or Family History of Cancer were expanded from personal history of colorectal and/or endometrial cancer to any Lynch Syndrome-related cancer.
  • Please see guidelines for many additional revisions based on tumor screening results; and refinement in care based on having an inherited colorectal cancer predisposing gene.

Permanent link to this article: https://inheritedcancer.net/icare-newsletter-spring-2024-national-comprehensive-cancer-network-nccn-guideline-updates/